Problem 4: The elimination half-life of tobramycin was reported to be 2.15 hours and the Vd was reported to be 33.5% of body weight. Assume that the drug is given by intravenous bolus injection every 8 hours.
a. What is the dose for an 80kg individual if a average steady-state level of 2.5 mg/L is desired?
b. Explain what will be the consequence if patient develop kidney or hepatic dysfunction.
Problem 5: The manufacturer has suggested that in normal cases, tobramycin should be given at a rate of 1 mg/kg every 8 hours. With this dosage regimen for the same patient at problem 4,
a. What would be the plasma average steady state level?